Bakke, Jesse
Ph.D.
Biography
Jesse Bakke is an associate professor of biochemistry within the Foundational Sciences Department of the CMU College of Medicine. He got his bachelor’s degree at the University of Hawaiʻi at Mānoa and his doctorate degree in nutritional biology with a designated emphasis in biotechnology at the University of California Davis. He completed a postdoctoral research fellowship at St. Jude Children’s Research Hospital. At CMU College of Medicine, Bakke leads large group, team-based learning, and case-based learning sessions as a content expert in biochemistry, cell biology, oncology and nutrition. Additionally, he has served as course director for several courses within the pre-clinical curriculum. Bakke’s lab primarily focuses on identifying novel genes and therapeutic targets within the broad field of oncology and cellular signaling using phenotypic CRISPR and siRNA screens.
More about Jesse Bakke
Publications & Presentations
Oladimeji PO, Bakke J, Wright WC, Chen T (2020). KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. Scientific reports.
Bakke J, Wright WC, Zamora AE, Oladimeji P, Crawford JC, Brewer CT, Autry RJ, Evans WE, Thomas PG, Chen T (2019). Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells. BMC cancer.
Zamora AE, Crawford JC, Allen EK, Guo XJ, Bakke J, Carter RA, Abdelsamed HA, Moustaki A, Li Y, Chang TC, Awad W, Dallas MH, Mullighan CG, Downing JR, Geiger TL, Chen T, Green DR, Youngblood BA, Zhang J, Thomas PG (2019). Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses. Science translational medicine.
Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T (2018). HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Oncogenesis.
Bakke J, Wright WC, Zamora AE, Ong SS, Wang YM, Hoyer JD, Brewer CT, Thomas PG, Chen T (2017). Transcription factor ZNF148 is a negative regulator of human muscle differentiation. Scientific reports.
Vitorino P, Yeung S, Crow A, Bakke J, Smyczek T, West K, McNamara E, Eastham-Anderson J, Gould S, Harris SF, Ndubaku C, Ye W (2015). MAP4K4 regulates integrin-FERM binding to control endothelial cell motility. Nature.
Bakke J, Haj FG (2015). Protein-tyrosine phosphatase 1B substrates and metabolic regulation. Seminars in cell & developmental biology.
Borkowski K, Wrzesinski K, Rogowska-Wrzesinska A, Audouze K, Bakke J, Petersen RK, Haj FG, Madsen L, Kristiansen K (2014). Proteomic analysis of cAMP-mediated signaling during differentiation of 3 T3-L1 preadipocytes. Biochimica et biophysica acta.
Bakke J, Bettaieb A, Nagata N, Matsuo K, Haj FG (2013). Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B. Cell communication and signaling : CCS.
Bettaieb A, Bakke J, Nagata N, Matsuo K, Xi Y, Liu S, AbouBechara D, Melhem R, Stanhope K, Cummings B, Graham J, Bremer A, Zhang S, Lyssiotis CA, Zhang ZY, Cantley LC, Havel PJ, Haj FG (2013). Protein tyrosine phosphatase 1B regulates pyruvate kinase M2 tyrosine phosphorylation. The Journal of biological chemistry.
Nagata N, Matsuo K, Bettaieb A, Bakke J, Matsuo I, Graham J, Xi Y, Liu S, Tomilov A, Tomilova N, Gray S, Jung DY, Ramsey JJ, Kim JK, Cortopassi G, Havel PJ, Haj FG (2012). Hepatic Src homology phosphatase 2 regulates energy balance in mice. Endocrinology.
Bettaieb A, Liu S, Xi Y, Nagata N, Matsuo K, Matsuo I, Chahed S, Bakke J, Keilhack H, Tiganis T, Haj FG (2011). Differential regulation of endoplasmic reticulum stress by protein tyrosine phosphatase 1B and T cell protein tyrosine phosphatase. The Journal of biological chemistry.
Franke AA, Morrison CM, Bakke JL, Custer LJ, Li X, Cooney RV (2010). Coenzyme Q10 in human blood: native levels and determinants of oxidation during processing and storage. Free radical biology & medicine.
Credentials, Certifications & Awards
Nutritional biology Graduate Student Fellowship
UCD and Humanities Graduate Research Award
Peter J. Shields and Henry A. Jastro Research Award
Education
Baccalaureate, University of Hawaii at Manoa
Membership in Professional Organizations
Association of Biochemistry Educators
AACR