Lewis, Kenneth
Ph.D.
Assistant Professor
Biography
Dr. Kenneth Lewis is an Assistant Professor of Physiology in the Department of Foundational Sciences at CMU College of Medicine. Originally from Rochester, Michigan where he studied biology at Oakland University before completing his Ph.D. at Wayne State University School of Medicine, studying mechanisms of membrane fusion and neurosecretion. He then went on to study adipocytes and their role in systemic metabolic homestasis during his postdoctoral training at University of Michigan Medical School. During his graduate and postdoctoral training, Dr. Lewis found a passion for teaching undergraduate, graduate, and medical students. As a member of the faculty at CMED, he plans to pursue teaching excellence and engage in medical education research.
More about Kenneth Lewis
Publications & Presentations
Arachchige MP, Laha SS, Naik AR, Lewis KT, Naik R, Jena BP (2017). Functionalized nanoparticles enable tracking the rapid entry and release of doxorubicin in human pancreatic cancer cells. Micron (Oxford, England : 1993).
Hou X, Lewis KT, Wu Q, Wang S, Chen X, Flack A, Mao G, Taatjes DJ, Sun F, Jena BP (2014). Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR). Journal of proteomics.
Lewis KT, Naik AR, Laha SS, Wang S, Mao G, Kuhn E, Jena BP (2018). Secretion induces cell pH dynamics impacting assembly-disassembly of the fusion protein complex: A combined fluorescence and atomic force microscopy study. Seminars in cell & developmental biology.
Romanelli SM, Lewis KT, Nishii A, Rupp AC, Li Z, Mori H, Schill RL, Learman BS, Rhodes CJ, MacDougald OA (2021). BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice. The Journal of biological chemistry.
Lewis KT, Maddipati KR, Naik AR, Jena BP (2017). Unique Lipid Chemistry of Synaptic Vesicle and Synaptosome Membrane Revealed Using Mass Spectrometry. ACS chemical neuroscience.
Naik AR, Lewis KT, Jena BP (2016). The neuronal porosome complex in health and disease. Experimental biology and medicine (Maywood, N.J.).
Hiroyuki Mori, Sydney K Peterson, Rachel C Simmermon, Katherine A Overmyer, Akira Nishii, Emma Paulsson, Ziru Li, Annie Jen, Romina M Uranga, Jessica N Maung, Warren T Yacawych, Kenneth T Lewis, Rebecca L Schill, Taryn Hetrick, Ryo Seino, Ken Inoki, Joshua J Coon, Ormond A MacDougald (2024). Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes Molecular Metabolism.
Naik AR, Kulkarni SP, Lewis KT, Taatjes DJ, Jena BP (2016). Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells. Endocrinology.
Lewis KT, Maddipati KR, Taatjes DJ, Jena BP (2014). Neuronal porosome lipidome. Journal of cellular and molecular medicine.
Jena BP, Stemmer PM, Wang S, Mao G, Lewis KT, Walz DA (2017). Human Platelet Vesicles Exhibit Distinct Size and Proteome. Journal of proteome research.
Shah C, Antonucci JV, Wilkinson JB, Wallace M, Ghilezan M, Chen P, Lewis K, Mitchell C, Vicini F (2011). Twelve-year clinical outcomes and patterns of failure with accelerated partial breast irradiation versus whole-breast irradiation: results of a matched-pair analysis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
Li Z, Bowers E, Zhu J, Yu H, Hardij J, Bagchi DP, Mori H, Lewis KT, Granger K, Schill RL, Romanelli SM, Abrishami S, Hankenson KD, Singer K, Rosen CJ, MacDougald OA (2022). Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits. eLife.
Akshata R. Naik, Eric R. Kuhn, Kenneth T. Lewis, Keith M. Kokotovich, Krishna R. Maddipati, Xuequn Chen, JHK Horber, Douglas J. Taatjes, Jeffrey J. Potoff, Bhanu P. Jena (2019). Self-Assembly and Biogenesis of the Cellular Membrane are Dictated by Membrane Stretch and Composition The Journal of Physical Chemistry B.
Li Z, Hardij J, Evers SS, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Bagchi DP, Romanelli SM, Kim KS, Bowers E, Griffin C, Seeley RJ, Singer K, Sandoval DA, Rosen CJ, MacDougald OA (2019). G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche. The Journal of clinical investigation.
Lewis KT, Oles LR, MacDougald OA (2022). Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element. Molecular metabolism.
Bagchi DP, Li Z, Corsa CA, Hardij J, Mori H, Learman BS, Lewis KT, Schill RL, Romanelli SM, MacDougald OA (2020). Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction. Molecular metabolism.
Corsa CAS, Walsh CM, Bagchi DP, Foss Freitas MC, Li Z, Hardij J, Granger K, Mori H, Schill RL, Lewis KT, Maung JN, Azaria RD, Rothberg AE, Oral EA, MacDougald OA (2021). Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2. Diabetes.
Akshata R. Naik, Sebastian Pernal, Kenneth T. Lewis, Yaobin Wu, Hongkai Wu, Nicholas J. Carruthers, Paul M. Stemmer, Bhanu P. Jena (2019). Human Skeletal Muscle Cells on Engineered 3D Platform Express Key Growth and Developmental Proteins ACS biomaterials science & engineering.
Rebecca L. Schill, Jack Visser, Mariah L. Ashby, Ziru Li, Kenneth T. Lewis, Antonio Morales-Hernandez, Keegan S. Hoose, Jessica N. Maung, Romina M. Uranga, Hadla Hariri, Isabel D. K. Hermsmeyer, Hiroyuki Mori, Ormond A. MacDougald (2024). Deficiency of glucocorticoid receptor in bone marrow adipocytes has mild effects on bone and hematopoiesis but does not influence expansion of marrow adiposity with caloric restriction Frontiers Endocrinology.
Kovari LC, Brunzelle JS, Lewis KT, Cho WJ, Lee JS, Taatjes DJ, Jena BP (2014). X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release. Micron (Oxford, England : 1993).
Rajagopal A, Kulkarni S, Lewis KT, Chen X, Maarouf A, Kelly CV, Taatjes DJ, Jena BP (2015). Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function. Journal of proteomics.
Hou X, Lewis KT, Wu Q, Wang S, Chen X, Flack A, Mao G, Taatjes DJ, Sun F, Jena BP (2014). Proteome of the porosome complex in human airway epithelia: interaction with the cystic fibrosis transmembrane conductance regulator (CFTR). Journal of proteomics.
Lewis KT, Naik AR, Laha SS, Wang S, Mao G, Kuhn E, Jena BP (2018). Secretion induces cell pH dynamics impacting assembly-disassembly of the fusion protein complex: A combined fluorescence and atomic force microscopy study. Seminars in cell & developmental biology.
Romanelli SM, Lewis KT, Nishii A, Rupp AC, Li Z, Mori H, Schill RL, Learman BS, Rhodes CJ, MacDougald OA (2021). BAd-CRISPR: Inducible gene knockout in interscapular brown adipose tissue of adult mice. The Journal of biological chemistry.
Lewis KT, Maddipati KR, Naik AR, Jena BP (2017). Unique Lipid Chemistry of Synaptic Vesicle and Synaptosome Membrane Revealed Using Mass Spectrometry. ACS chemical neuroscience.
Naik AR, Lewis KT, Jena BP (2016). The neuronal porosome complex in health and disease. Experimental biology and medicine (Maywood, N.J.).
Hiroyuki Mori, Sydney K Peterson, Rachel C Simmermon, Katherine A Overmyer, Akira Nishii, Emma Paulsson, Ziru Li, Annie Jen, Romina M Uranga, Jessica N Maung, Warren T Yacawych, Kenneth T Lewis, Rebecca L Schill, Taryn Hetrick, Ryo Seino, Ken Inoki, Joshua J Coon, Ormond A MacDougald (2024). Scd1 and monounsaturated lipids are required for autophagy and survival of adipocytes Molecular Metabolism.
Naik AR, Kulkarni SP, Lewis KT, Taatjes DJ, Jena BP (2016). Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells. Endocrinology.
Lewis KT, Maddipati KR, Taatjes DJ, Jena BP (2014). Neuronal porosome lipidome. Journal of cellular and molecular medicine.
Jena BP, Stemmer PM, Wang S, Mao G, Lewis KT, Walz DA (2017). Human Platelet Vesicles Exhibit Distinct Size and Proteome. Journal of proteome research.
Shah C, Antonucci JV, Wilkinson JB, Wallace M, Ghilezan M, Chen P, Lewis K, Mitchell C, Vicini F (2011). Twelve-year clinical outcomes and patterns of failure with accelerated partial breast irradiation versus whole-breast irradiation: results of a matched-pair analysis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
Li Z, Bowers E, Zhu J, Yu H, Hardij J, Bagchi DP, Mori H, Lewis KT, Granger K, Schill RL, Romanelli SM, Abrishami S, Hankenson KD, Singer K, Rosen CJ, MacDougald OA (2022). Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits. eLife.
Akshata R. Naik, Eric R. Kuhn, Kenneth T. Lewis, Keith M. Kokotovich, Krishna R. Maddipati, Xuequn Chen, JHK Horber, Douglas J. Taatjes, Jeffrey J. Potoff, Bhanu P. Jena (2019). Self-Assembly and Biogenesis of the Cellular Membrane are Dictated by Membrane Stretch and Composition The Journal of Physical Chemistry B.
Li Z, Hardij J, Evers SS, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Bagchi DP, Romanelli SM, Kim KS, Bowers E, Griffin C, Seeley RJ, Singer K, Sandoval DA, Rosen CJ, MacDougald OA (2019). G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche. The Journal of clinical investigation.
Lewis KT, Oles LR, MacDougald OA (2022). Tetracycline response element driven Cre causes ectopic recombinase activity independent of transactivator element. Molecular metabolism.
Bagchi DP, Li Z, Corsa CA, Hardij J, Mori H, Learman BS, Lewis KT, Schill RL, Romanelli SM, MacDougald OA (2020). Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction. Molecular metabolism.
Corsa CAS, Walsh CM, Bagchi DP, Foss Freitas MC, Li Z, Hardij J, Granger K, Mori H, Schill RL, Lewis KT, Maung JN, Azaria RD, Rothberg AE, Oral EA, MacDougald OA (2021). Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2. Diabetes.
Akshata R. Naik, Sebastian Pernal, Kenneth T. Lewis, Yaobin Wu, Hongkai Wu, Nicholas J. Carruthers, Paul M. Stemmer, Bhanu P. Jena (2019). Human Skeletal Muscle Cells on Engineered 3D Platform Express Key Growth and Developmental Proteins ACS biomaterials science & engineering.
Rebecca L. Schill, Jack Visser, Mariah L. Ashby, Ziru Li, Kenneth T. Lewis, Antonio Morales-Hernandez, Keegan S. Hoose, Jessica N. Maung, Romina M. Uranga, Hadla Hariri, Isabel D. K. Hermsmeyer, Hiroyuki Mori, Ormond A. MacDougald (2024). Deficiency of glucocorticoid receptor in bone marrow adipocytes has mild effects on bone and hematopoiesis but does not influence expansion of marrow adiposity with caloric restriction Frontiers Endocrinology.
Kovari LC, Brunzelle JS, Lewis KT, Cho WJ, Lee JS, Taatjes DJ, Jena BP (2014). X-ray solution structure of the native neuronal porosome-synaptic vesicle complex: Implication in neurotransmitter release. Micron (Oxford, England : 1993).
Rajagopal A, Kulkarni S, Lewis KT, Chen X, Maarouf A, Kelly CV, Taatjes DJ, Jena BP (2015). Proteome of the insulin-secreting Min6 cell porosome complex: involvement of Hsp90 in its assembly and function. Journal of proteomics.
Education
B.S., Oakland University, Rochester, Michigan (MI)
Ph.D., Wayne State University School of Medicine, Detroit, Michigan (MI)
Ph.D., Wayne State University School of Medicine, Detroit, Michigan (MI)
Membership in Professional Organizations
International Association of Medical Science Educators (IAMSE)
AAMC Central Group on Educational Affairs (CGEA)
American Physiological Society
AAMC Central Group on Educational Affairs (CGEA)
American Physiological Society