Petersen, Robert
Ph.D.
Professor with Tenure
Biography
Dr. Petersen is a Professor of Cell Biology, Genetics and Neuroscience. He received his B.S in Biochemistry, magna cum laude, from the University of Minnesota as well as his Ph.D. in Cell and Developmental Biology. He was a post-doctoral Fellow with Dr. Susan Lindquist at the University of Chicago before joining the Faculty at Case Western Reserve University where he rose through the ranks to Full Professor. His research has spanned post-transcriptional mechanisms for controlling gene expression to the discovery of a novel genetic mechanism that regulates disease phenotype. For his scientific accomplishments he was elected a Fellow of the American Association for the Advancement of Science in 2017. In education, Dr. Petersen has extensive experience in small group facilitation. He served as the Assistant Dean for Basic Science Education at Case and as the Assistant Director of their small group Program. He joined the Faculty at the CMU College of Medicine in 2017 and teaches cell biology, genetics and neuroscience.
More about Robert Petersen
Publications & Presentations
Wong BS, Pan T, Liu T, Li R, Petersen RB, Jones IM, Gambetti P, Brown DR, Sy MS (2000). Prion disease: A loss of antioxidant function? Biochemical and biophysical research communications.
Yu S, Yin S, Pham N, Wong P, Kang SC, Petersen RB, Li C, Sy MS (2008). Ligand binding promotes prion protein aggregation--role of the octapeptide repeats. The FEBS journal.
Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ (2019). Publisher Correction: Early preclinical detection of prions in the skin of prion-infected animals. Nature communications.
Chen H, Wan D, Wang L, Peng A, Xiao H, Petersen RB, Liu C, Zheng L, Huang K (2015). Apelin protects against acute renal injury by inhibiting TGF-β1. Biochimica et biophysica acta.
Li R, Liu D, Zanusso G, Liu T, Fayen JD, Huang JH, Petersen RB, Gambetti P, Sy MS (2001). The expression and potential function of cellular prion protein in human lymphocytes. Cellular immunology.
Rodrigues R, Smith MA, Wang X, Perry G, Lee HG, Zhu X, Petersen RB (2012). Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress. Future neurology.
Srinageshwar B, Petersen RB, Dunbar GL, Rossignol J (2020). Prion-like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy. Stem cells translational medicine.
Petersen RB (2002). You can take the genome out of the organism, but can you take the organism out of the environment? Journal of Alzheimer's disease : JAD.
Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA (2008). Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. Journal of neurochemistry.
Chapman J, Cervenáková L, Petersen RB, Lee HS, Estupinan J, Richardson S, Vnencak-Jones CL, Gajdusek DC, Korczyn AD, Brown P, Goldfarb LG (1998). APOE in non-Alzheimer amyloidoses: transmissible spongiform encephalopathies. Neurology.
Zhang B, Cowden D, Zhang F, Yuan J, Siedlak S, Abouelsaad M, Zeng L, Zhou X, O'Toole J, Das AS, Kofskey D, Warren M, Bian Z, Cui Y, Tan T, Kresak A, Wyza RE, Petersen RB, Wang GX, Kong Q, Wang X, Sedor J, Zhu X, Zhu H, Zou WQ (2015). Correction: Prion Protein Protects against Renal Ischemia/Reperfusion Injury. PloS one.
Capellari S, Parchi P, Russo CM, Sanford J, Sy MS, Gambetti P, Petersen RB (2000). Effect of the E200K mutation on prion protein metabolism. Comparative study of a cell model and human brain. The American journal of pathology.
Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG (2008). Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordrecht, Netherlands).
Zhang Y, Zhao Y, Wang Z, Gong H, Ma L, Sun D, Yang C, Li Y, Cheng B, Petersen RB, Jiang F, Liu G, Huang K (2018). Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1-42). Biochimica et biophysica acta. General subjects.
Zhang W, Yang D, Yuan Y, Liu C, Chen H, Zhang Y, Wang Q, Petersen RB, Huang K, Zheng L (2020). Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice. Diabetes.
Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G (2000). Protein disulfide isomerase in Alzheimer disease. Antioxidants & redox signaling.
Capellari S, Zaidi SI, Urig CB, Perry G, Smith MA, Petersen RB (1999). Prion protein glycosylation is sensitive to redox change. The Journal of biological chemistry.
Moreira PI, Zhu X, Wang X, Lee HG, Nunomura A, Petersen RB, Perry G, Smith MA (2010). Mitochondria: a therapeutic target in neurodegeneration. Biochimica et biophysica acta.
Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG (2007). The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Experimental cell research.
Tabaton M, Rolleri M, Masturzo P, Cammarata S, Angelini G, Hansen LA, Saitoh T, Petersen RB, Perry G, Richey P (1995). Apolipoprotein E epsilon 4 allele frequency is not increased in progressive supranuclear palsy. Neurology.
Parchi P, Castellani R, Capellari S, Ghetti B, Young K, Chen SG, Farlow M, Dickson DW, Sima AA, Trojanowski JQ, Petersen RB, Gambetti P (1996). Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease. Annals of neurology.
Lee HG, Petersen RB, Zhu X, Honda K, Aliev G, Smith MA, Perry G (2003). Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases? Brain pathology (Zurich, Switzerland).
Cheng B, Gong H, Xiao H, Petersen RB, Zheng L, Huang K (2013). Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases. Biochimica et biophysica acta.
Rubenstein R, Bulgin MS, Chang B, Sorensen-Melson S, Petersen RB, LaFauci G (2012). PrP(Sc) detection and infectivity in semen from scrapie-infected sheep. The Journal of general virology.
Petersen RB, Hackett PB (1985). Characterization of ribosome binding on Rous sarcoma virus RNA in vitro. Journal of virology.
Zhao L, Guo H, Chen H, Petersen RB, Zheng L, Peng A, Huang K (2013). Effect of Liraglutide on endoplasmic reticulum stress in diabetes. Biochemical and biophysical research communications.
Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG (2016). Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. PloS one.
Xie Z, O'Rourke KI, Dong Z, Jenny AL, Langenberg JA, Belay ED, Schonberger LB, Petersen RB, Zou W, Kong Q, Gambetti P, Chen SG (2006). Chronic wasting disease of elk and deer and Creutzfeldt-Jakob disease: comparative analysis of the scrapie prion protein. The Journal of biological chemistry.
Yuan Y, Liu C, Chen X, Sun Y, Xiong M, Fan Y, Petersen RB, Chen H, Huang K, Zheng L (2021). Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress. Molecular nutrition & food research.
Li Y, Yang C, Wang S, Yang D, Zhang Y, Xu L, Ma L, Zheng J, Petersen RB, Zheng L, Chen H, Huang K (2020). Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease. International journal of biological macromolecules.
Petersen RB, Goldfarb LG, Tabaton M, Brown P, Monari L, Cortelli P, Montagna P, Autilio-Gambetti L, Gajdusek DC, Lugaresi E (1994). A novel mechanism of phenotypic heterogeneity demonstrated by the effect of a polymorphism on a pathogenic mutation in the PRNP (prion protein gene). Molecular neurobiology.
Shen P, Dang J, Wang Z, Zhang W, Yuan J, Lang Y, Ding M, Mitchell M, Kong Q, Feng J, Rozemuller AJM, Cui L, Petersen RB, Zou WQ (2021). Characterization of Anchorless Human PrP With Q227X Stop Mutation Linked to Gerstmann-Sträussler-Scheinker Syndrome In Vivo and In Vitro. Molecular neurobiology.
Parchi P, Petersen RB, Chen SG, Autilio-Gambetti L, Capellari S, Monari L, Cortelli P, Montagna P, Lugaresi E, Gambetti P (1998). Molecular pathology of fatal familial insomnia. Brain pathology (Zurich, Switzerland).
Rodrigues R, Petersen RB, Perry G (2014). Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability. Cellular and molecular neurobiology.
Gong H, Yang X, Zhao Y, Petersen RB, Liu X, Liu Y, Huang K (2015). Amyloidogenicity of p53: a hidden link between protein misfolding and cancer. Current protein & peptide science.
Hackett PB, Petersen RB, Hensel CH, Albericio F, Gunderson SI, Palmenberg AC, Barany G (1986). Synthesis in vitro of a seven amino acid peptide encoded in the leader RNA of Rous sarcoma virus. Journal of molecular biology.
Petersen RB, Tabaton M, Berg L, Schrank B, Torack RM, Leal S, Julien J, Vital C, Deleplanque B, Pendlebury WW (1992). Analysis of the prion protein gene in thalamic dementia. Neurology.
Capellari S, Zaidi SI, Long AC, Kwon EE, Petersen RB (2000). The Thr183Ala Mutation, Not the Loss of the First Glycosylation Site, Alters the Physical Properties of the Prion Protein. Journal of Alzheimer's disease : JAD.
Chen H, Li J, Jiao L, Petersen RB, Li J, Peng A, Zheng L, Huang K (2014). Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse. The Journal of physiology.
Gambetti P, Parchi P, Petersen RB, Chen SG, Lugaresi E (1995). Fatal familial insomnia and familial Creutzfeldt-Jakob disease: clinical, pathological and molecular features. Brain pathology (Zurich, Switzerland).
Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG (2016). Correction: Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. PloS one.
Lu K, Wang W, Xie Z, Wong BS, Li R, Petersen RB, Sy MS, Chen SG (2000). Expression and structural characterization of the recombinant human doppel protein. Biochemistry.
Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Lee HG, Kim YS, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L (2019). Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation. Molecular neurobiology.
Wang W, Wang Q, Wan D, Sun Y, Wang L, Chen H, Liu C, Petersen RB, Li J, Xue W, Zheng L, Huang K (2017). Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy. Autophagy.
Petersen RB, Lindquist S (1989). Regulation of HSP70 synthesis by messenger RNA degradation. Cell regulation.
Hensel CH, Petersen RB, Hackett PB (1989). Effects of alterations in the leader sequence of Rous sarcoma virus RNA on initiation of translation. Journal of virology.
Hackett PB, Dalton MW, Johnson DP, Petersen RB (1991). Phylogenetic and physical analysis of the 5' leader RNA sequences of avian retroviruses. Nucleic acids research.
Petersen RB, Moustakas A, Hackett PB (1989). A mutation in the short 5'-proximal open reading frame on Rous sarcoma virus RNA alters virus production. Journal of virology.
Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA (2009). The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. The American journal of pathology.
Petersen RB (1999). Antemortem diagnosis of variant Creutzfeldt-Jakob disease. Lancet (London, England).
Liu T, Li R, Pan T, Liu D, Petersen RB, Wong BS, Gambetti P, Sy MS (2002). Intercellular transfer of the cellular prion protein. The Journal of biological chemistry.
Reed-Cossairt A, Zhu X, Lee HG, Reed C, Perry G, Petersen RB (2012). Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome. Current gerontology and geriatrics research.
Li Y, Wang Z, Chen Y, Petersen RB, Zheng L, Huang K (2019). Salvation of the fallen angel: Reactivating mutant p53. British journal of pharmacology.
Sparks DL, Connor DJ, Sabbagh MN, Petersen RB, Lopez J, Browne P (2006). Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial. Acta neurologica Scandinavica. Supplementum.
Sun Y, Wang Q, Zhang Y, Geng M, Wei Y, Liu Y, Liu S, Petersen RB, Yue J, Huang K, Zheng L (2020). Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p. Journal of hepatology.
Golic MM, Rong YS, Petersen RB, Lindquist SL, Golic KG (1997). FLP-mediated DNA mobilization to specific target sites in Drosophila chromosomes. Nucleic acids research.
Yang J, Song QY, Niu SX, Chen HJ, Petersen RB, Zhang Y, Huang K (2021). Emerging roles of angiopoietin-like proteins in inflammation: Mechanisms and potential as pharmacological targets. Journal of cellular physiology.
Parchi P, Castellani R, Cortelli P, Montagna P, Chen SG, Petersen RB, Manetto V, Vnencak-Jones CL, McLean MJ, Sheller JR (1995). Regional distribution of protease-resistant prion protein in fatal familial insomnia. Annals of neurology.
Zhang X, Liu J, Huang L, Yang X, Petersen RB, Sun Y, Gong H, Zheng L, Huang K (2016). How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study. Biochimica et biophysica acta.
Monari L, Chen SG, Brown P, Parchi P, Petersen RB, Mikol J, Gray F, Cortelli P, Montagna P, Ghetti B (1994). Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism. Proceedings of the National Academy of Sciences of the United States of America.
Liu T, Zwingman T, Li R, Pan T, Wong BS, Petersen RB, Gambetti P, Herrup K, Sy MS (2001). Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies. Brain research.
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA (2001). Mitochondrial abnormalities in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P (2005). Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Rolston RK, Perry G, Zhu X, Castellani RJ, Dwyer BE, Lee HG, Petersen RB, Smith MA (2009). Iron: A Pathological Mediator of Alzheimer Disease? Agro food industry hi-tech.
Thompson C, Otero P, Srinageshwar B, Petersen RB, Dunbar GL, Rossignol J (2020). Possible roles of epigenetics in stem cell therapy for Parkinson's disease. Epigenomics.
Petersen RB, Hensel CH, Hackett PB (1984). Identification of a ribosome-binding site for a leader peptide encoded by Rous sarcoma virus RNA. Journal of virology.
Singh N, Zanusso G, Chen SG, Fujioka H, Richardson S, Gambetti P, Petersen RB (1997). Prion protein aggregation reverted by low temperature in transfected cells carrying a prion protein gene mutation. The Journal of biological chemistry.
Singh A, Kong Q, Luo X, Petersen RB, Meyerson H, Singh N (2009). Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. PloS one.
Capellari S, Vital C, Parchi P, Petersen RB, Ferrer X, Jarnier D, Pegoraro E, Gambetti P, Julien J (1997). Familial prion disease with a novel 144-bp insertion in the prion protein gene in a Basque family. Neurology.
Wong BS, Liu T, Li R, Pan T, Petersen RB, Smith MA, Gambetti P, Perry G, Manson JC, Brown DR, Sy MS (2001). Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. Journal of neurochemistry.
Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, Petersen RB, Perry G (2004). Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. Journal of Alzheimer's disease : JAD.
Liu X, Chen Y, Li Y, Petersen RB, Huang K (2019). Targeting mitosis exit: A brake for cancer cell proliferation. Biochimica et biophysica acta. Reviews on cancer.
Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ (2013). Glycoform-selective prion formation in sporadic and familial forms of prion disease. PloS one.
Zhan YA, Abskharon R, Li Y, Yuan J, Zeng L, Dang J, Martinez MC, Wang Z, Mikol J, Lehmann S, Bu S, Steyaert J, Cui L, Petersen RB, Kong Q, Wang GX, Wohlkonig A, Zou WQ (2016). Quiescin-sulfhydryl oxidase inhibits prion formation in vitro. Aging.
Lindquist S, Petersen R (1990). Selective translation and degradation of heat-shock messenger RNAs in Drosophila. Enzyme.
Dagvadorj A, Petersen RB, Lee HS, Cervenakova L, Shatunov A, Budka H, Brown P, Gambetti P, Goldfarb LG (2002). Spontaneous mutations in the prion protein gene causing transmissible spongiform encephalopathy. Annals of neurology.
Yu J, Nagarajan S, Ueda E, Knez JJ, Petersen RB, Medof ME (1994). Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
Zhu X, Castellani RJ, Ziats NP, Petersen RB, Gon Lee H, Perry G (2012). Mark A. Smith: neurocytochemistry innovator. Journal of neurochemistry.
Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, Perry G (2005). Redox metals and oxidative abnormalities in human prion diseases. Acta neuropathologica.
Quan C, Chen Y, Wang X, Yang D, Wang Q, Huang Y, Petersen RB, Liu X, Zheng L, Li Y, Huang K (2020). Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Cancer letters.
Yost HJ, Petersen RB, Lindquist S (1990). RNA metabolism: strategies for regulation in the heat shock response. Trends in genetics : TIG.
LaFauci G, Carp RI, Meeker HC, Ye X, Kim JI, Natelli M, Cedeno M, Petersen RB, Kascsak R, Rubenstein R (2006). Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC. The Journal of general virology.
Siu IM, Robinson DR, Schwartz S, Kung HJ, Pretlow TG, Petersen RB, Pretlow TP (1999). The identification of monoclonality in human aberrant crypt foci. Cancer research.
Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ (2019). Early preclinical detection of prions in the skin of prion-infected animals. Nature communications.
Capellari S, Parchi P, Wolff BD, Campbell J, Atkinson R, Posey DM, Petersen RB, Gambetti P (2002). Creutzfeldt-Jakob disease associated with a deletion of two repeats in the prion protein gene. Neurology.
Petersen R, Lindquist S (1988). The Drosophila hsp70 message is rapidly degraded at normal temperatures and stabilized by heat shock. Gene.
Dellavalle RP, Petersen R, Lindquist S (1994). Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogaster. Molecular and cellular biology.
Wang S, Zheng J, Ma L, Petersen RB, Xu L, Huang K (2022). Inhibiting protein aggregation with nanomaterials: The underlying mechanisms and impact factors. Biochimica et biophysica acta. General subjects.
Brown BG, Josephson MA, Petersen RB, Pierce CD, Wong M, Hecht HS, Bolson E, Dodge HT (1981). Intravenous dipyridamole combined with isometric handgrip for near maximal acute increase in coronary flow in patients with coronary artery disease. The American journal of cardiology.
Fan Y, Yuan Y, Xiong M, Jin M, Zhang D, Yang D, Liu C, Petersen RB, Huang K, Peng A, Zheng L (2023). Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase. Theranostics.
Yang C, Xu H, Yang D, Xie Y, Xiong M, Fan Y, Liu X, Zhang Y, Xiao Y, Chen Y, Zhou Y, Song L, Wang C, Peng A, Petersen RB, Chen H, Huang K, Zheng L (2023). A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury. Nature communications.
Xiong M, Chen H, Fan Y, Jin M, Yang D, Chen Y, Zhang Y, Petersen RB, Su H, Peng A, Wang C, Zheng L, Huang K (2023). Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation. Theranostics.
Ma L, Li X, Petersen RB, Peng A, Huang K (2023). Probing the interactions between amyloidogenic proteins and bio-membranes. Biophysical chemistry.
Petersen RB, Walter B (2023). Editorial: Insights into Parkinson's disease and aging related movement disorders. Frontiers in aging neuroscience.
Yang D, Fan Y, Xiong M, Chen Y, Zhou Y, Liu X, Yuan Y, Wang Q, Zhang Y, Petersen RB, Su H, Yue J, Zhang C, Chen H, Huang K, Zheng L (2023). Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1. EMBO reports.
McShea A, Lee HG, Petersen RB, Casadesus G, Vincent I, Linford NJ, Funk JO, Shapiro RA, Smith MA (2007). Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochimica et biophysica acta.
Ma L, Li X, Liu C, Yan W, Ma J, Petersen RB, Peng A, Huang K (2022). Modelling Parkinson's Disease in C. elegans: Strengths and Limitations. Current pharmaceutical design.
Pan T, Colucci M, Wong BS, Li R, Liu T, Petersen RB, Chen S, Gambetti P, Sy MS (2001). Novel differences between two human prion strains revealed by two-dimensional gel electrophoresis. The Journal of biological chemistry.
Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG (2012). Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Human molecular genetics.
Goedert M, Spillantini MG, Crowther RA, Chen SG, Parchi P, Tabaton M, Lanska DJ, Markesbery WR, Wilhelmsen KC, Dickson DW, Petersen RB, Gambetti P (1999). Tau gene mutation in familial progressive subcortical gliosis. Nature medicine.
Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X (2007). Signal transduction cascades associated with oxidative stress in Alzheimer's disease. Journal of Alzheimer's disease : JAD.
Sun Y, Geng M, Yuan Y, Guo P, Chen Y, Yang D, Petersen RB, Huang K, Zheng L (2020). Lmo4-resistin signaling contributes to adipose tissue-liver crosstalk upon weight cycling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
Zhang B, Cowden D, Zhang F, Yuan J, Siedlak S, Abouelsaad M, Zeng L, Zhou X, O'Toole J, Das AS, Kofskey D, Warren M, Bian Z, Cui Y, Tan T, Kresak A, Wyza RE, Petersen RB, Wang GX, Kong Q, Wang X, Sedor J, Zhu X, Zhu H, Zou WQ (2015). Prion Protein Protects against Renal Ischemia/Reperfusion Injury. PloS one.
Liu T, Li R, Wong BS, Liu D, Pan T, Petersen RB, Gambetti P, Sy MS (2001). Normal cellular prion protein is preferentially expressed on subpopulations of murine hemopoietic cells. Journal of immunology (Baltimore, Md. : 1950).
Wang W, Arakawa H, Wang L, Okolo O, Siedlak SL, Jiang Y, Gao J, Xie F, Petersen RB, Wang X (2017). Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization. Molecular therapy : the journal of the American Society of Gene Therapy.
Petersen RB, Tabaton M, Chen SG, Monari L, Richardson SL, Lynch T, Manetto V, Lanska DJ, Markesbery WR, Lynches T [corrected to Lynch T] (1995). Familial progressive subcortical gliosis: presence of prions and linkage to chromosome 17. Neurology.
Kim HJ, Choi HS, Park JH, Kim MJ, Lee HG, Petersen RB, Kim YS, Park JB, Choi EK (2017). Regulation of RhoA activity by the cellular prion protein. Cell death & disease.
Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, Groveman BR, Petersen RB, Ironside JW, Quiñones-Mateu ME, Safar JG, Kong Q, Caughey B, Zou WQ (2017). Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease. Science translational medicine.
Petersen RB, Parchi P, Richardson SL, Urig CB, Gambetti P (1996). Effect of the D178N mutation and the codon 129 polymorphism on the metabolism of the prion protein. The Journal of biological chemistry.
Kudo W, Petersen RB, Lee HG (2013). Cellular prion protein and Alzheimer disease: link to oligomeric amyloid-β and neuronal cell death. Prion.
Cheng B, Li Y, Ma L, Wang Z, Petersen RB, Zheng L, Chen Y, Huang K (2018). Interaction between amyloidogenic proteins and biomembranes in protein misfolding diseases: Mechanisms, contributors, and therapy. Biochimica et biophysica acta. Biomembranes.
Cai R, Xue W, Liu S, Petersen RB, Huang K, Zheng L (2015). Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
Friedland RP, Petersen RB, Rubenstein R (2009). Bovine spongiform encephalopathy and aquaculture. Journal of Alzheimer's disease : JAD.
Grant MP, Cohen M, Petersen RB, Halmagyi GM, McDougall A, Tusa RJ, Leigh RJ (1993). Abnormal eye movements in Creutzfeldt-Jakob disease. Annals of neurology.
Gong H, Yang X, Zhao Y, Petersen RB, Liu X, Liu Y, Huang K (2014). Amyloidogenicity of p53: A Hidden Link Between Protein Misfolding and Cancer. Current protein & peptide science.
Raymond GJ, Hope J, Kocisko DA, Priola SA, Raymond LD, Bossers A, Ironside J, Will RG, Chen SG, Petersen RB, Gambetti P, Rubenstein R, Smits MA, Lansbury PT Jr, Caughey B (1997). Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature.
Perry G, Taddeo MA, Petersen RB, Castellani RJ, Harris PL, Siedlak SL, Cash AD, Liu Q, Nunomura A, Atwood CS, Smith MA (2003). Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
Parchi P, Capellari S, Chen SG, Petersen RB, Gambetti P, Kopp N, Brown P, Kitamoto T, Tateishi J, Giese A, Kretzschmar H (1997). Typing prion isoforms. Nature.
Liu X, Zhou Y, Liu X, Peng A, Gong H, Huang L, Ji K, Petersen RB, Zheng L, Huang K (2014). MPHOSPH1: a potential therapeutic target for hepatocellular carcinoma. Cancer research.
Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA (2004). Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of neurochemistry.
Yuan J, Dong Z, Guo JP, McGeehan J, Xiao X, Wang J, Cali I, McGeer PL, Cashman NR, Bessen R, Surewicz WK, Kneale G, Petersen RB, Gambetti P, Zou WQ (2008). Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions. Cellular and molecular life sciences : CMLS.
Wong BS, Liu T, Paisley D, Li R, Pan T, Chen SG, Perry G, Petersen RB, Smith MA, Melton DW, Gambetti P, Brown DR, Sy MS (2001). Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function. Molecular and cellular neurosciences.
Perry G, Nunomura A, Raina AK, Aliev G, Siedlak SL, Harris PL, Casadesus G, Petersen RB, Bligh-Glover W, Balraj E, Petot GJ, Smith MA (2003). A metabolic basis for Alzheimer disease. Neurochemical research.
Pan T, Wong BS, Liu T, Li R, Petersen RB, Sy MS (2002). Cell-surface prion protein interacts with glycosaminoglycans. The Biochemical journal.
Swietnicki W, Petersen RB, Gambetti P, Surewicz WK (1998). Familial mutations and the thermodynamic stability of the recombinant human prion protein. The Journal of biological chemistry.
Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP (2011). Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. The Journal of biological chemistry.
Goldfarb LG, Petersen RB, Tabaton M, Brown P, LeBlanc AC, Montagna P, Cortelli P, Julien J, Vital C, Pendelbury WW (1992). Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism. Science (New York, N.Y.).
Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ (2013). Recombinant human prion protein inhibits prion propagation in vitro. Scientific reports.
Santos RX, Correia SC, Zhu X, Lee HG, Petersen RB, Nunomura A, Smith MA, Perry G, Moreira PI (2012). Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free radical research.
Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA (2009). Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochemistry international.
Lee HG, Ogawa O, Zhu X, O'Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA (2004). Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease. Acta neuropathologica.
Petersen RB, Lissemore FM, Appleby B, Aggarwal N, Boyatzis R, Casadesus G, Cummings J, Jack A, Perry G, Safar J, Sajatovic M, Surewicz WK, Wang Y, Whitehouse P, Lerner A (2015). From Neurodegeneration to Brain Health: An Integrated Approach. Journal of Alzheimer's disease : JAD.
Zhu X, Raina AK, Lee HG, Chao M, Nunomura A, Tabaton M, Petersen RB, Perry G, Smith MA (2003). Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. Antioxidants & redox signaling.
Zaidi SI, Richardson SL, Capellari S, Song L, Smith MA, Ghetti B, Sy MS, Gambetti P, Petersen RB (2005). Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding. Journal of Alzheimer's disease : JAD.
Zheng C, Li X, Kong C, Ke S, Peng C, Cui T, Gao M, Zhou Y, Guo W, Huang L, Petersen RB, Huang K (2015). Effect of single nucleotide polymorphism in thrombin-activatable fibrinolysis inhibitor on the risk of diabetic macrovascular disease. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X (2012). Untangling the vascular web from Alzheimer disease and oxidative stress. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
Wang J, Xiao Y, Liu C, Huang Y, Petersen RB, Zheng L, Huang K (2021). Emerging physiological and pathological roles of MeCP2 in non-neurological systems. Archives of biochemistry and biophysics.
Liu Z, Reba S, Chen WD, Porwal SK, Boom WH, Petersen RB, Rojas R, Viswanathan R, Devireddy L (2014). Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection. The Journal of experimental medicine.
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA (2001). Oxidative damage is the earliest event in Alzheimer disease. Journal of neuropathology and experimental neurology.
Petersen RB, Goren H, Cohen M, Richardson SL, Tresser N, Lynn A, Gali M, Estes M, Gambetti P (1997). Transthyretin amyloidosis: a new mutation associated with dementia. Annals of neurology.
Premkumar DR, Smith MA, Richey PL, Petersen RB, Castellani R, Kutty RK, Wiggert B, Perry G, Kalaria RN (1995). Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. Journal of neurochemistry.
Smith MA, Kutty RK, Richey PL, Yan SD, Stern D, Chader GJ, Wiggert B, Petersen RB, Perry G (1994). Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. The American journal of pathology.
Zou RS, Fujioka H, Guo JP, Xiao X, Shimoji M, Kong C, Chen C, Tasnadi M, Voma C, Yuan J, Moudjou M, Laude H, Petersen RB, Zou WQ (2011). Characterization of spontaneously generated prion-like conformers in cultured cells. Aging.
Zanusso G, Liu D, Ferrari S, Hegyi I, Yin X, Aguzzi A, Hornemann S, Liemann S, Glockshuber R, Manson JC, Brown P, Petersen RB, Gambetti P, Sy MS (1998). Prion protein expression in different species: analysis with a panel of new mAbs. Proceedings of the National Academy of Sciences of the United States of America.
Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Lee HG, Kim YS, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L (2019). In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation. Molecular neurobiology.
Zanusso G, Petersen RB, Jin T, Jing Y, Kanoush R, Ferrari S, Gambetti P, Singh N (1999). Proteasomal degradation and N-terminal protease resistance of the codon 145 mutant prion protein. The Journal of biological chemistry.
Takeda A, Perry G, Abraham NG, Dwyer BE, Kutty RK, Laitinen JT, Petersen RB, Smith MA (2000). Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau. The Journal of biological chemistry.
Aliev G, Castellani RJ, Petersen RB, Burnstock G, Perry G, Smith MA (2004). Pathobiology of familial hypercholesterolemic atherosclerosis. Journal of submicroscopic cytology and pathology.
Vital C, Gray F, Vital A, Parchi P, Capellari S, Petersen RB, Ferrer X, Jarnier D, Julien J, Gambetti P (1998). Prion encephalopathy with insertion of octapeptide repeats: the number of repeats determines the type of cerebellar deposits. Neuropathology and applied neurobiology.
Honda K, Casadesus G, Petersen RB, Perry G, Smith MA (2004). Oxidative stress and redox-active iron in Alzheimer's disease. Annals of the New York Academy of Sciences.
Wang X, Snape M, Klann E, Stone JG, Singh A, Petersen RB, Castellani RJ, Casadesus G, Smith MA, Zhu X (2012). Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. Journal of neurochemistry.
Gerst JL, Raina AK, Pirim I, McShea A, Harris PL, Siedlak SL, Takeda A, Petersen RB, Smith MA (2000). Altered cell-matrix associated ADAM proteins in Alzheimer disease. Journal of neuroscience research.
Ding Y, Li J, Liu S, Zhang L, Xiao H, Li J, Chen H, Petersen RB, Huang K, Zheng L (2014). DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding. International journal of obesity (2005).
Yu S, Yin S, Pham N, Wong P, Kang SC, Petersen RB, Li C, Sy MS (2008). Ligand binding promotes prion protein aggregation--role of the octapeptide repeats. The FEBS journal.
Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ (2019). Publisher Correction: Early preclinical detection of prions in the skin of prion-infected animals. Nature communications.
Chen H, Wan D, Wang L, Peng A, Xiao H, Petersen RB, Liu C, Zheng L, Huang K (2015). Apelin protects against acute renal injury by inhibiting TGF-β1. Biochimica et biophysica acta.
Li R, Liu D, Zanusso G, Liu T, Fayen JD, Huang JH, Petersen RB, Gambetti P, Sy MS (2001). The expression and potential function of cellular prion protein in human lymphocytes. Cellular immunology.
Rodrigues R, Smith MA, Wang X, Perry G, Lee HG, Zhu X, Petersen RB (2012). Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress. Future neurology.
Srinageshwar B, Petersen RB, Dunbar GL, Rossignol J (2020). Prion-like mechanisms in neurodegenerative disease: Implications for Huntington's disease therapy. Stem cells translational medicine.
Petersen RB (2002). You can take the genome out of the organism, but can you take the organism out of the environment? Journal of Alzheimer's disease : JAD.
Gustaw KA, Garrett MR, Lee HG, Castellani RJ, Zagorski MG, Prakasam A, Siedlak SL, Zhu X, Perry G, Petersen RB, Friedland RP, Smith MA (2008). Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis. Journal of neurochemistry.
Chapman J, Cervenáková L, Petersen RB, Lee HS, Estupinan J, Richardson S, Vnencak-Jones CL, Gajdusek DC, Korczyn AD, Brown P, Goldfarb LG (1998). APOE in non-Alzheimer amyloidoses: transmissible spongiform encephalopathies. Neurology.
Zhang B, Cowden D, Zhang F, Yuan J, Siedlak S, Abouelsaad M, Zeng L, Zhou X, O'Toole J, Das AS, Kofskey D, Warren M, Bian Z, Cui Y, Tan T, Kresak A, Wyza RE, Petersen RB, Wang GX, Kong Q, Wang X, Sedor J, Zhu X, Zhu H, Zou WQ (2015). Correction: Prion Protein Protects against Renal Ischemia/Reperfusion Injury. PloS one.
Capellari S, Parchi P, Russo CM, Sanford J, Sy MS, Gambetti P, Petersen RB (2000). Effect of the E200K mutation on prion protein metabolism. Comparative study of a cell model and human brain. The American journal of pathology.
Myung NH, Zhu X, Kruman II, Castellani RJ, Petersen RB, Siedlak SL, Perry G, Smith MA, Lee HG (2008). Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordrecht, Netherlands).
Zhang Y, Zhao Y, Wang Z, Gong H, Ma L, Sun D, Yang C, Li Y, Cheng B, Petersen RB, Jiang F, Liu G, Huang K (2018). Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1-42). Biochimica et biophysica acta. General subjects.
Zhang W, Yang D, Yuan Y, Liu C, Chen H, Zhang Y, Wang Q, Petersen RB, Huang K, Zheng L (2020). Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice. Diabetes.
Kim HT, Russell RL, Raina AK, Harris PL, Siedlak SL, Zhu X, Petersen RB, Shimohama S, Smith MA, Perry G (2000). Protein disulfide isomerase in Alzheimer disease. Antioxidants & redox signaling.
Capellari S, Zaidi SI, Urig CB, Perry G, Smith MA, Petersen RB (1999). Prion protein glycosylation is sensitive to redox change. The Journal of biological chemistry.
Moreira PI, Zhu X, Wang X, Lee HG, Nunomura A, Petersen RB, Perry G, Smith MA (2010). Mitochondria: a therapeutic target in neurodegeneration. Biochimica et biophysica acta.
Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG (2007). The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Experimental cell research.
Tabaton M, Rolleri M, Masturzo P, Cammarata S, Angelini G, Hansen LA, Saitoh T, Petersen RB, Perry G, Richey P (1995). Apolipoprotein E epsilon 4 allele frequency is not increased in progressive supranuclear palsy. Neurology.
Parchi P, Castellani R, Capellari S, Ghetti B, Young K, Chen SG, Farlow M, Dickson DW, Sima AA, Trojanowski JQ, Petersen RB, Gambetti P (1996). Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease. Annals of neurology.
Lee HG, Petersen RB, Zhu X, Honda K, Aliev G, Smith MA, Perry G (2003). Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases? Brain pathology (Zurich, Switzerland).
Cheng B, Gong H, Xiao H, Petersen RB, Zheng L, Huang K (2013). Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases. Biochimica et biophysica acta.
Rubenstein R, Bulgin MS, Chang B, Sorensen-Melson S, Petersen RB, LaFauci G (2012). PrP(Sc) detection and infectivity in semen from scrapie-infected sheep. The Journal of general virology.
Petersen RB, Hackett PB (1985). Characterization of ribosome binding on Rous sarcoma virus RNA in vitro. Journal of virology.
Zhao L, Guo H, Chen H, Petersen RB, Zheng L, Peng A, Huang K (2013). Effect of Liraglutide on endoplasmic reticulum stress in diabetes. Biochemical and biophysical research communications.
Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG (2016). Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. PloS one.
Xie Z, O'Rourke KI, Dong Z, Jenny AL, Langenberg JA, Belay ED, Schonberger LB, Petersen RB, Zou W, Kong Q, Gambetti P, Chen SG (2006). Chronic wasting disease of elk and deer and Creutzfeldt-Jakob disease: comparative analysis of the scrapie prion protein. The Journal of biological chemistry.
Yuan Y, Liu C, Chen X, Sun Y, Xiong M, Fan Y, Petersen RB, Chen H, Huang K, Zheng L (2021). Vitamin C Inhibits the Metabolic Changes Induced by Tet1 Insufficiency Under High Fat Diet Stress. Molecular nutrition & food research.
Li Y, Yang C, Wang S, Yang D, Zhang Y, Xu L, Ma L, Zheng J, Petersen RB, Zheng L, Chen H, Huang K (2020). Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease. International journal of biological macromolecules.
Petersen RB, Goldfarb LG, Tabaton M, Brown P, Monari L, Cortelli P, Montagna P, Autilio-Gambetti L, Gajdusek DC, Lugaresi E (1994). A novel mechanism of phenotypic heterogeneity demonstrated by the effect of a polymorphism on a pathogenic mutation in the PRNP (prion protein gene). Molecular neurobiology.
Shen P, Dang J, Wang Z, Zhang W, Yuan J, Lang Y, Ding M, Mitchell M, Kong Q, Feng J, Rozemuller AJM, Cui L, Petersen RB, Zou WQ (2021). Characterization of Anchorless Human PrP With Q227X Stop Mutation Linked to Gerstmann-Sträussler-Scheinker Syndrome In Vivo and In Vitro. Molecular neurobiology.
Parchi P, Petersen RB, Chen SG, Autilio-Gambetti L, Capellari S, Monari L, Cortelli P, Montagna P, Lugaresi E, Gambetti P (1998). Molecular pathology of fatal familial insomnia. Brain pathology (Zurich, Switzerland).
Rodrigues R, Petersen RB, Perry G (2014). Parallels between major depressive disorder and Alzheimer's disease: role of oxidative stress and genetic vulnerability. Cellular and molecular neurobiology.
Gong H, Yang X, Zhao Y, Petersen RB, Liu X, Liu Y, Huang K (2015). Amyloidogenicity of p53: a hidden link between protein misfolding and cancer. Current protein & peptide science.
Hackett PB, Petersen RB, Hensel CH, Albericio F, Gunderson SI, Palmenberg AC, Barany G (1986). Synthesis in vitro of a seven amino acid peptide encoded in the leader RNA of Rous sarcoma virus. Journal of molecular biology.
Petersen RB, Tabaton M, Berg L, Schrank B, Torack RM, Leal S, Julien J, Vital C, Deleplanque B, Pendlebury WW (1992). Analysis of the prion protein gene in thalamic dementia. Neurology.
Capellari S, Zaidi SI, Long AC, Kwon EE, Petersen RB (2000). The Thr183Ala Mutation, Not the Loss of the First Glycosylation Site, Alters the Physical Properties of the Prion Protein. Journal of Alzheimer's disease : JAD.
Chen H, Li J, Jiao L, Petersen RB, Li J, Peng A, Zheng L, Huang K (2014). Apelin inhibits the development of diabetic nephropathy by regulating histone acetylation in Akita mouse. The Journal of physiology.
Gambetti P, Parchi P, Petersen RB, Chen SG, Lugaresi E (1995). Fatal familial insomnia and familial Creutzfeldt-Jakob disease: clinical, pathological and molecular features. Brain pathology (Zurich, Switzerland).
Blair JA, Wang C, Hernandez D, Siedlak SL, Rodgers MS, Achar RK, Fahmy LM, Torres SL, Petersen RB, Zhu X, Casadesus G, Lee HG (2016). Correction: Individual Case Analysis of Postmortem Interval Time on Brain Tissue Preservation. PloS one.
Lu K, Wang W, Xie Z, Wong BS, Li R, Petersen RB, Sy MS, Chen SG (2000). Expression and structural characterization of the recombinant human doppel protein. Biochemistry.
Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Lee HG, Kim YS, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L (2019). Correction to: In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation. Molecular neurobiology.
Wang W, Wang Q, Wan D, Sun Y, Wang L, Chen H, Liu C, Petersen RB, Li J, Xue W, Zheng L, Huang K (2017). Histone HIST1H1C/H1.2 regulates autophagy in the development of diabetic retinopathy. Autophagy.
Petersen RB, Lindquist S (1989). Regulation of HSP70 synthesis by messenger RNA degradation. Cell regulation.
Hensel CH, Petersen RB, Hackett PB (1989). Effects of alterations in the leader sequence of Rous sarcoma virus RNA on initiation of translation. Journal of virology.
Hackett PB, Dalton MW, Johnson DP, Petersen RB (1991). Phylogenetic and physical analysis of the 5' leader RNA sequences of avian retroviruses. Nucleic acids research.
Petersen RB, Moustakas A, Hackett PB (1989). A mutation in the short 5'-proximal open reading frame on Rous sarcoma virus RNA alters virus production. Journal of virology.
Lee HG, Casadesus G, Nunomura A, Zhu X, Castellani RJ, Richardson SL, Perry G, Felsher DW, Petersen RB, Smith MA (2009). The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse. The American journal of pathology.
Petersen RB (1999). Antemortem diagnosis of variant Creutzfeldt-Jakob disease. Lancet (London, England).
Liu T, Li R, Pan T, Liu D, Petersen RB, Wong BS, Gambetti P, Sy MS (2002). Intercellular transfer of the cellular prion protein. The Journal of biological chemistry.
Reed-Cossairt A, Zhu X, Lee HG, Reed C, Perry G, Petersen RB (2012). Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome. Current gerontology and geriatrics research.
Li Y, Wang Z, Chen Y, Petersen RB, Zheng L, Huang K (2019). Salvation of the fallen angel: Reactivating mutant p53. British journal of pharmacology.
Sparks DL, Connor DJ, Sabbagh MN, Petersen RB, Lopez J, Browne P (2006). Circulating cholesterol levels, apolipoprotein E genotype and dementia severity influence the benefit of atorvastatin treatment in Alzheimer's disease: results of the Alzheimer's Disease Cholesterol-Lowering Treatment (ADCLT) trial. Acta neurologica Scandinavica. Supplementum.
Sun Y, Wang Q, Zhang Y, Geng M, Wei Y, Liu Y, Liu S, Petersen RB, Yue J, Huang K, Zheng L (2020). Multigenerational maternal obesity increases the incidence of HCC in offspring via miR-27a-3p. Journal of hepatology.
Golic MM, Rong YS, Petersen RB, Lindquist SL, Golic KG (1997). FLP-mediated DNA mobilization to specific target sites in Drosophila chromosomes. Nucleic acids research.
Yang J, Song QY, Niu SX, Chen HJ, Petersen RB, Zhang Y, Huang K (2021). Emerging roles of angiopoietin-like proteins in inflammation: Mechanisms and potential as pharmacological targets. Journal of cellular physiology.
Parchi P, Castellani R, Cortelli P, Montagna P, Chen SG, Petersen RB, Manetto V, Vnencak-Jones CL, McLean MJ, Sheller JR (1995). Regional distribution of protease-resistant prion protein in fatal familial insomnia. Annals of neurology.
Zhang X, Liu J, Huang L, Yang X, Petersen RB, Sun Y, Gong H, Zheng L, Huang K (2016). How the imidazole ring modulates amyloid formation of islet amyloid polypeptide: A chemical modification study. Biochimica et biophysica acta.
Monari L, Chen SG, Brown P, Parchi P, Petersen RB, Mikol J, Gray F, Cortelli P, Montagna P, Ghetti B (1994). Fatal familial insomnia and familial Creutzfeldt-Jakob disease: different prion proteins determined by a DNA polymorphism. Proceedings of the National Academy of Sciences of the United States of America.
Liu T, Zwingman T, Li R, Pan T, Wong BS, Petersen RB, Gambetti P, Herrup K, Sy MS (2001). Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies. Brain research.
Hirai K, Aliev G, Nunomura A, Fujioka H, Russell RL, Atwood CS, Johnson AB, Kress Y, Vinters HV, Tabaton M, Shimohama S, Cash AD, Siedlak SL, Harris PL, Jones PK, Petersen RB, Perry G, Smith MA (2001). Mitochondrial abnormalities in Alzheimer's disease. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, Yuan J, Zheng M, Bai H, Deng H, Chen K, Jenny AL, O'Rourke K, Belay ED, Schonberger LB, Petersen RB, Sy MS, Chen SG, Gambetti P (2005). Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models. The Journal of neuroscience : the official journal of the Society for Neuroscience.
Rolston RK, Perry G, Zhu X, Castellani RJ, Dwyer BE, Lee HG, Petersen RB, Smith MA (2009). Iron: A Pathological Mediator of Alzheimer Disease? Agro food industry hi-tech.
Thompson C, Otero P, Srinageshwar B, Petersen RB, Dunbar GL, Rossignol J (2020). Possible roles of epigenetics in stem cell therapy for Parkinson's disease. Epigenomics.
Petersen RB, Hensel CH, Hackett PB (1984). Identification of a ribosome-binding site for a leader peptide encoded by Rous sarcoma virus RNA. Journal of virology.
Singh N, Zanusso G, Chen SG, Fujioka H, Richardson S, Gambetti P, Petersen RB (1997). Prion protein aggregation reverted by low temperature in transfected cells carrying a prion protein gene mutation. The Journal of biological chemistry.
Singh A, Kong Q, Luo X, Petersen RB, Meyerson H, Singh N (2009). Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport. PloS one.
Capellari S, Vital C, Parchi P, Petersen RB, Ferrer X, Jarnier D, Pegoraro E, Gambetti P, Julien J (1997). Familial prion disease with a novel 144-bp insertion in the prion protein gene in a Basque family. Neurology.
Wong BS, Liu T, Li R, Pan T, Petersen RB, Smith MA, Gambetti P, Perry G, Manson JC, Brown DR, Sy MS (2001). Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein. Journal of neurochemistry.
Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, Petersen RB, Perry G (2004). Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. Journal of Alzheimer's disease : JAD.
Liu X, Chen Y, Li Y, Petersen RB, Huang K (2019). Targeting mitosis exit: A brake for cancer cell proliferation. Biochimica et biophysica acta. Reviews on cancer.
Xiao X, Yuan J, Haïk S, Cali I, Zhan Y, Moudjou M, Li B, Laplanche JL, Laude H, Langeveld J, Gambetti P, Kitamoto T, Kong Q, Brandel JP, Cobb BA, Petersen RB, Zou WQ (2013). Glycoform-selective prion formation in sporadic and familial forms of prion disease. PloS one.
Zhan YA, Abskharon R, Li Y, Yuan J, Zeng L, Dang J, Martinez MC, Wang Z, Mikol J, Lehmann S, Bu S, Steyaert J, Cui L, Petersen RB, Kong Q, Wang GX, Wohlkonig A, Zou WQ (2016). Quiescin-sulfhydryl oxidase inhibits prion formation in vitro. Aging.
Lindquist S, Petersen R (1990). Selective translation and degradation of heat-shock messenger RNAs in Drosophila. Enzyme.
Dagvadorj A, Petersen RB, Lee HS, Cervenakova L, Shatunov A, Budka H, Brown P, Gambetti P, Goldfarb LG (2002). Spontaneous mutations in the prion protein gene causing transmissible spongiform encephalopathy. Annals of neurology.
Yu J, Nagarajan S, Ueda E, Knez JJ, Petersen RB, Medof ME (1994). Characterization of alternatively spliced PIG-A transcripts in normal and paroxysmal nocturnal hemoglobinuria cells. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
Zhu X, Castellani RJ, Ziats NP, Petersen RB, Gon Lee H, Perry G (2012). Mark A. Smith: neurocytochemistry innovator. Journal of neurochemistry.
Petersen RB, Siedlak SL, Lee HG, Kim YS, Nunomura A, Tagliavini F, Ghetti B, Cras P, Moreira PI, Castellani RJ, Guentchev M, Budka H, Ironside JW, Gambetti P, Smith MA, Perry G (2005). Redox metals and oxidative abnormalities in human prion diseases. Acta neuropathologica.
Quan C, Chen Y, Wang X, Yang D, Wang Q, Huang Y, Petersen RB, Liu X, Zheng L, Li Y, Huang K (2020). Loss of histone lysine methyltransferase EZH2 confers resistance to tyrosine kinase inhibitors in non-small cell lung cancer. Cancer letters.
Yost HJ, Petersen RB, Lindquist S (1990). RNA metabolism: strategies for regulation in the heat shock response. Trends in genetics : TIG.
LaFauci G, Carp RI, Meeker HC, Ye X, Kim JI, Natelli M, Cedeno M, Petersen RB, Kascsak R, Rubenstein R (2006). Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC. The Journal of general virology.
Siu IM, Robinson DR, Schwartz S, Kung HJ, Pretlow TG, Petersen RB, Pretlow TP (1999). The identification of monoclonality in human aberrant crypt foci. Cancer research.
Wang Z, Manca M, Foutz A, Camacho MV, Raymond GJ, Race B, Orru CD, Yuan J, Shen P, Li B, Lang Y, Dang J, Adornato A, Williams K, Maurer NR, Gambetti P, Xu B, Surewicz W, Petersen RB, Dong X, Appleby BS, Caughey B, Cui L, Kong Q, Zou WQ (2019). Early preclinical detection of prions in the skin of prion-infected animals. Nature communications.
Capellari S, Parchi P, Wolff BD, Campbell J, Atkinson R, Posey DM, Petersen RB, Gambetti P (2002). Creutzfeldt-Jakob disease associated with a deletion of two repeats in the prion protein gene. Neurology.
Petersen R, Lindquist S (1988). The Drosophila hsp70 message is rapidly degraded at normal temperatures and stabilized by heat shock. Gene.
Dellavalle RP, Petersen R, Lindquist S (1994). Preferential deadenylation of Hsp70 mRNA plays a key role in regulating Hsp70 expression in Drosophila melanogaster. Molecular and cellular biology.
Wang S, Zheng J, Ma L, Petersen RB, Xu L, Huang K (2022). Inhibiting protein aggregation with nanomaterials: The underlying mechanisms and impact factors. Biochimica et biophysica acta. General subjects.
Brown BG, Josephson MA, Petersen RB, Pierce CD, Wong M, Hecht HS, Bolson E, Dodge HT (1981). Intravenous dipyridamole combined with isometric handgrip for near maximal acute increase in coronary flow in patients with coronary artery disease. The American journal of cardiology.
Fan Y, Yuan Y, Xiong M, Jin M, Zhang D, Yang D, Liu C, Petersen RB, Huang K, Peng A, Zheng L (2023). Tet1 deficiency exacerbates oxidative stress in acute kidney injury by regulating superoxide dismutase. Theranostics.
Yang C, Xu H, Yang D, Xie Y, Xiong M, Fan Y, Liu X, Zhang Y, Xiao Y, Chen Y, Zhou Y, Song L, Wang C, Peng A, Petersen RB, Chen H, Huang K, Zheng L (2023). A renal YY1-KIM1-DR5 axis regulates the progression of acute kidney injury. Nature communications.
Xiong M, Chen H, Fan Y, Jin M, Yang D, Chen Y, Zhang Y, Petersen RB, Su H, Peng A, Wang C, Zheng L, Huang K (2023). Tubular Elabela-APJ axis attenuates ischemia-reperfusion induced acute kidney injury and the following AKI-CKD transition by protecting renal microcirculation. Theranostics.
Ma L, Li X, Petersen RB, Peng A, Huang K (2023). Probing the interactions between amyloidogenic proteins and bio-membranes. Biophysical chemistry.
Petersen RB, Walter B (2023). Editorial: Insights into Parkinson's disease and aging related movement disorders. Frontiers in aging neuroscience.
Yang D, Fan Y, Xiong M, Chen Y, Zhou Y, Liu X, Yuan Y, Wang Q, Zhang Y, Petersen RB, Su H, Yue J, Zhang C, Chen H, Huang K, Zheng L (2023). Loss of renal tubular G9a benefits acute kidney injury by lowering focal lipid accumulation via CES1. EMBO reports.
McShea A, Lee HG, Petersen RB, Casadesus G, Vincent I, Linford NJ, Funk JO, Shapiro RA, Smith MA (2007). Neuronal cell cycle re-entry mediates Alzheimer disease-type changes. Biochimica et biophysica acta.
Ma L, Li X, Liu C, Yan W, Ma J, Petersen RB, Peng A, Huang K (2022). Modelling Parkinson's Disease in C. elegans: Strengths and Limitations. Current pharmaceutical design.
Pan T, Colucci M, Wong BS, Li R, Liu T, Petersen RB, Chen S, Gambetti P, Sy MS (2001). Novel differences between two human prion strains revealed by two-dimensional gel electrophoresis. The Journal of biological chemistry.
Kudo W, Lee HP, Zou WQ, Wang X, Perry G, Zhu X, Smith MA, Petersen RB, Lee HG (2012). Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death. Human molecular genetics.
Goedert M, Spillantini MG, Crowther RA, Chen SG, Parchi P, Tabaton M, Lanska DJ, Markesbery WR, Wilhelmsen KC, Dickson DW, Petersen RB, Gambetti P (1999). Tau gene mutation in familial progressive subcortical gliosis. Nature medicine.
Petersen RB, Nunomura A, Lee HG, Casadesus G, Perry G, Smith MA, Zhu X (2007). Signal transduction cascades associated with oxidative stress in Alzheimer's disease. Journal of Alzheimer's disease : JAD.
Sun Y, Geng M, Yuan Y, Guo P, Chen Y, Yang D, Petersen RB, Huang K, Zheng L (2020). Lmo4-resistin signaling contributes to adipose tissue-liver crosstalk upon weight cycling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
Zhang B, Cowden D, Zhang F, Yuan J, Siedlak S, Abouelsaad M, Zeng L, Zhou X, O'Toole J, Das AS, Kofskey D, Warren M, Bian Z, Cui Y, Tan T, Kresak A, Wyza RE, Petersen RB, Wang GX, Kong Q, Wang X, Sedor J, Zhu X, Zhu H, Zou WQ (2015). Prion Protein Protects against Renal Ischemia/Reperfusion Injury. PloS one.
Liu T, Li R, Wong BS, Liu D, Pan T, Petersen RB, Gambetti P, Sy MS (2001). Normal cellular prion protein is preferentially expressed on subpopulations of murine hemopoietic cells. Journal of immunology (Baltimore, Md. : 1950).
Wang W, Arakawa H, Wang L, Okolo O, Siedlak SL, Jiang Y, Gao J, Xie F, Petersen RB, Wang X (2017). Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization. Molecular therapy : the journal of the American Society of Gene Therapy.
Petersen RB, Tabaton M, Chen SG, Monari L, Richardson SL, Lynch T, Manetto V, Lanska DJ, Markesbery WR, Lynches T [corrected to Lynch T] (1995). Familial progressive subcortical gliosis: presence of prions and linkage to chromosome 17. Neurology.
Kim HJ, Choi HS, Park JH, Kim MJ, Lee HG, Petersen RB, Kim YS, Park JB, Choi EK (2017). Regulation of RhoA activity by the cellular prion protein. Cell death & disease.
Orrú CD, Yuan J, Appleby BS, Li B, Li Y, Winner D, Wang Z, Zhan YA, Rodgers M, Rarick J, Wyza RE, Joshi T, Wang GX, Cohen ML, Zhang S, Groveman BR, Petersen RB, Ironside JW, Quiñones-Mateu ME, Safar JG, Kong Q, Caughey B, Zou WQ (2017). Prion seeding activity and infectivity in skin samples from patients with sporadic Creutzfeldt-Jakob disease. Science translational medicine.
Petersen RB, Parchi P, Richardson SL, Urig CB, Gambetti P (1996). Effect of the D178N mutation and the codon 129 polymorphism on the metabolism of the prion protein. The Journal of biological chemistry.
Kudo W, Petersen RB, Lee HG (2013). Cellular prion protein and Alzheimer disease: link to oligomeric amyloid-β and neuronal cell death. Prion.
Cheng B, Li Y, Ma L, Wang Z, Petersen RB, Zheng L, Chen Y, Huang K (2018). Interaction between amyloidogenic proteins and biomembranes in protein misfolding diseases: Mechanisms, contributors, and therapy. Biochimica et biophysica acta. Biomembranes.
Cai R, Xue W, Liu S, Petersen RB, Huang K, Zheng L (2015). Overexpression of glyceraldehyde 3-phosphate dehydrogenase prevents neurovascular degeneration after retinal injury. FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
Friedland RP, Petersen RB, Rubenstein R (2009). Bovine spongiform encephalopathy and aquaculture. Journal of Alzheimer's disease : JAD.
Grant MP, Cohen M, Petersen RB, Halmagyi GM, McDougall A, Tusa RJ, Leigh RJ (1993). Abnormal eye movements in Creutzfeldt-Jakob disease. Annals of neurology.
Gong H, Yang X, Zhao Y, Petersen RB, Liu X, Liu Y, Huang K (2014). Amyloidogenicity of p53: A Hidden Link Between Protein Misfolding and Cancer. Current protein & peptide science.
Raymond GJ, Hope J, Kocisko DA, Priola SA, Raymond LD, Bossers A, Ironside J, Will RG, Chen SG, Petersen RB, Gambetti P, Rubenstein R, Smits MA, Lansbury PT Jr, Caughey B (1997). Molecular assessment of the potential transmissibilities of BSE and scrapie to humans. Nature.
Perry G, Taddeo MA, Petersen RB, Castellani RJ, Harris PL, Siedlak SL, Cash AD, Liu Q, Nunomura A, Atwood CS, Smith MA (2003). Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease. Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
Parchi P, Capellari S, Chen SG, Petersen RB, Gambetti P, Kopp N, Brown P, Kitamoto T, Tateishi J, Giese A, Kretzschmar H (1997). Typing prion isoforms. Nature.
Liu X, Zhou Y, Liu X, Peng A, Gong H, Huang L, Ji K, Petersen RB, Zheng L, Huang K (2014). MPHOSPH1: a potential therapeutic target for hepatocellular carcinoma. Cancer research.
Zhu X, Wang Y, Ogawa O, Lee HG, Raina AK, Siedlak SL, Harris PL, Fujioka H, Shimohama S, Tabaton M, Atwood CS, Petersen RB, Perry G, Smith MA (2004). Neuroprotective properties of Bcl-w in Alzheimer disease. Journal of neurochemistry.
Yuan J, Dong Z, Guo JP, McGeehan J, Xiao X, Wang J, Cali I, McGeer PL, Cashman NR, Bessen R, Surewicz WK, Kneale G, Petersen RB, Gambetti P, Zou WQ (2008). Accessibility of a critical prion protein region involved in strain recognition and its implications for the early detection of prions. Cellular and molecular life sciences : CMLS.
Wong BS, Liu T, Paisley D, Li R, Pan T, Chen SG, Perry G, Petersen RB, Smith MA, Melton DW, Gambetti P, Brown DR, Sy MS (2001). Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function. Molecular and cellular neurosciences.
Perry G, Nunomura A, Raina AK, Aliev G, Siedlak SL, Harris PL, Casadesus G, Petersen RB, Bligh-Glover W, Balraj E, Petot GJ, Smith MA (2003). A metabolic basis for Alzheimer disease. Neurochemical research.
Pan T, Wong BS, Liu T, Li R, Petersen RB, Sy MS (2002). Cell-surface prion protein interacts with glycosaminoglycans. The Biochemical journal.
Swietnicki W, Petersen RB, Gambetti P, Surewicz WK (1998). Familial mutations and the thermodynamic stability of the recombinant human prion protein. The Journal of biological chemistry.
Zou WQ, Xiao X, Yuan J, Puoti G, Fujioka H, Wang X, Richardson S, Zhou X, Zou R, Li S, Zhu X, McGeer PL, McGeehan J, Kneale G, Rincon-Limas DE, Fernandez-Funez P, Lee HG, Smith MA, Petersen RB, Guo JP (2011). Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. The Journal of biological chemistry.
Goldfarb LG, Petersen RB, Tabaton M, Brown P, LeBlanc AC, Montagna P, Cortelli P, Julien J, Vital C, Pendelbury WW (1992). Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism. Science (New York, N.Y.).
Yuan J, Zhan YA, Abskharon R, Xiao X, Martinez MC, Zhou X, Kneale G, Mikol J, Lehmann S, Surewicz WK, Castilla J, Steyaert J, Zhang S, Kong Q, Petersen RB, Wohlkonig A, Zou WQ (2013). Recombinant human prion protein inhibits prion propagation in vitro. Scientific reports.
Santos RX, Correia SC, Zhu X, Lee HG, Petersen RB, Nunomura A, Smith MA, Perry G, Moreira PI (2012). Nuclear and mitochondrial DNA oxidation in Alzheimer's disease. Free radical research.
Lee HG, Casadesus G, Zhu X, Castellani RJ, McShea A, Perry G, Petersen RB, Bajic V, Smith MA (2009). Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease. Neurochemistry international.
Lee HG, Ogawa O, Zhu X, O'Neill MJ, Petersen RB, Castellani RJ, Ghanbari H, Perry G, Smith MA (2004). Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease. Acta neuropathologica.
Petersen RB, Lissemore FM, Appleby B, Aggarwal N, Boyatzis R, Casadesus G, Cummings J, Jack A, Perry G, Safar J, Sajatovic M, Surewicz WK, Wang Y, Whitehouse P, Lerner A (2015). From Neurodegeneration to Brain Health: An Integrated Approach. Journal of Alzheimer's disease : JAD.
Zhu X, Raina AK, Lee HG, Chao M, Nunomura A, Tabaton M, Petersen RB, Perry G, Smith MA (2003). Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways. Antioxidants & redox signaling.
Zaidi SI, Richardson SL, Capellari S, Song L, Smith MA, Ghetti B, Sy MS, Gambetti P, Petersen RB (2005). Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding. Journal of Alzheimer's disease : JAD.
Zheng C, Li X, Kong C, Ke S, Peng C, Cui T, Gao M, Zhou Y, Guo W, Huang L, Petersen RB, Huang K (2015). Effect of single nucleotide polymorphism in thrombin-activatable fibrinolysis inhibitor on the risk of diabetic macrovascular disease. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
Perry G, Phelix CF, Nunomura A, Colom LV, Castellani RJ, Petersen RB, Lee HG, Zhu X (2012). Untangling the vascular web from Alzheimer disease and oxidative stress. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
Wang J, Xiao Y, Liu C, Huang Y, Petersen RB, Zheng L, Huang K (2021). Emerging physiological and pathological roles of MeCP2 in non-neurological systems. Archives of biochemistry and biophysics.
Liu Z, Reba S, Chen WD, Porwal SK, Boom WH, Petersen RB, Rojas R, Viswanathan R, Devireddy L (2014). Regulation of mammalian siderophore 2,5-DHBA in the innate immune response to infection. The Journal of experimental medicine.
Nunomura A, Perry G, Aliev G, Hirai K, Takeda A, Balraj EK, Jones PK, Ghanbari H, Wataya T, Shimohama S, Chiba S, Atwood CS, Petersen RB, Smith MA (2001). Oxidative damage is the earliest event in Alzheimer disease. Journal of neuropathology and experimental neurology.
Petersen RB, Goren H, Cohen M, Richardson SL, Tresser N, Lynn A, Gali M, Estes M, Gambetti P (1997). Transthyretin amyloidosis: a new mutation associated with dementia. Annals of neurology.
Premkumar DR, Smith MA, Richey PL, Petersen RB, Castellani R, Kutty RK, Wiggert B, Perry G, Kalaria RN (1995). Induction of heme oxygenase-1 mRNA and protein in neocortex and cerebral vessels in Alzheimer's disease. Journal of neurochemistry.
Smith MA, Kutty RK, Richey PL, Yan SD, Stern D, Chader GJ, Wiggert B, Petersen RB, Perry G (1994). Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease. The American journal of pathology.
Zou RS, Fujioka H, Guo JP, Xiao X, Shimoji M, Kong C, Chen C, Tasnadi M, Voma C, Yuan J, Moudjou M, Laude H, Petersen RB, Zou WQ (2011). Characterization of spontaneously generated prion-like conformers in cultured cells. Aging.
Zanusso G, Liu D, Ferrari S, Hegyi I, Yin X, Aguzzi A, Hornemann S, Liemann S, Glockshuber R, Manson JC, Brown P, Petersen RB, Gambetti P, Sy MS (1998). Prion protein expression in different species: analysis with a panel of new mAbs. Proceedings of the National Academy of Sciences of the United States of America.
Wang Z, Yuan J, Shen P, Abskharon R, Lang Y, Dang J, Adornato A, Xu L, Chen J, Feng J, Moudjou M, Kitamoto T, Lee HG, Kim YS, Langeveld J, Appleby B, Ma J, Kong Q, Petersen RB, Zou WQ, Cui L (2019). In Vitro Seeding Activity of Glycoform-Deficient Prions from Variably Protease-Sensitive Prionopathy and Familial CJD Associated with PrPV180I Mutation. Molecular neurobiology.
Zanusso G, Petersen RB, Jin T, Jing Y, Kanoush R, Ferrari S, Gambetti P, Singh N (1999). Proteasomal degradation and N-terminal protease resistance of the codon 145 mutant prion protein. The Journal of biological chemistry.
Takeda A, Perry G, Abraham NG, Dwyer BE, Kutty RK, Laitinen JT, Petersen RB, Smith MA (2000). Overexpression of heme oxygenase in neuronal cells, the possible interaction with Tau. The Journal of biological chemistry.
Aliev G, Castellani RJ, Petersen RB, Burnstock G, Perry G, Smith MA (2004). Pathobiology of familial hypercholesterolemic atherosclerosis. Journal of submicroscopic cytology and pathology.
Vital C, Gray F, Vital A, Parchi P, Capellari S, Petersen RB, Ferrer X, Jarnier D, Julien J, Gambetti P (1998). Prion encephalopathy with insertion of octapeptide repeats: the number of repeats determines the type of cerebellar deposits. Neuropathology and applied neurobiology.
Honda K, Casadesus G, Petersen RB, Perry G, Smith MA (2004). Oxidative stress and redox-active iron in Alzheimer's disease. Annals of the New York Academy of Sciences.
Wang X, Snape M, Klann E, Stone JG, Singh A, Petersen RB, Castellani RJ, Casadesus G, Smith MA, Zhu X (2012). Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. Journal of neurochemistry.
Gerst JL, Raina AK, Pirim I, McShea A, Harris PL, Siedlak SL, Takeda A, Petersen RB, Smith MA (2000). Altered cell-matrix associated ADAM proteins in Alzheimer disease. Journal of neuroscience research.
Ding Y, Li J, Liu S, Zhang L, Xiao H, Li J, Chen H, Petersen RB, Huang K, Zheng L (2014). DNA hypomethylation of inflammation-associated genes in adipose tissue of female mice after multigenerational high fat diet feeding. International journal of obesity (2005).
Credentials, Certifications & Awards
Michael E. Lamm Excellence in Graduate Student Teaching Award
John R. Carter Excellence in Medical Student Teaching
Kavli Foundation Frontiers in Science Alumni 1996 German-American Frontiers
AAAS Fellow
John R. Carter Excellence in Medical Student Teaching
Kavli Foundation Frontiers in Science Alumni 1996 German-American Frontiers
AAAS Fellow
Education
B.S. Magna Cum Laude, University of Minnesota, St. Paul, Minnesota (MN)
Ph.D., University of Minnesota, St. Paul, Minnesota (MN)
Ph.D., University of Minnesota, St. Paul, Minnesota (MN)
Membership in Professional Organizations
American Association for the Advancement of Science
American Society for Microbiology
American Society of Neuroscience
International Association of Medical Science Educators
American Chemical Society
American Society for Cell Biology
American Society for Microbiology
American Society of Neuroscience
International Association of Medical Science Educators
American Chemical Society
American Society for Cell Biology